We all think of infertile as the term that describes couples who can’t get pregnant.


But not so fast…


We have an important note for patients.


The medical definition of infertility is “the inability to become pregnant after one year of regular sexual intercourse.” But this definition is far from perfect. It does not take into account many related personal factors, and the truth is that many couples diagnosed with infertility eventually conceive and have healthy pregnancies and babies.


So why the label infertile?


At Reply, we do not categorize a couple as infertile just because a year has passed without a pregnancy. Instead, we use the term subfertile, which we believe is more accurate. Subfertile means less than normal fertility—in medical terms, “the inability to become pregnant after six months of regular intercourse.” We describe all couples who have not yet had a full fertility evaluation that uncovered a specific cause of infertility as subfertile, rather than infertile.


This terminology reinforces that our goal is to correct the underlying causes of fertility problems. Our cooperative approach at Reply means we work hard to look for, and treat, the root causes of the patient’s fertility problem, because we know that fertility problems often have multiple factors, and often require a thorough work-up.


Physicians and medical researchers in Europe have used the term subfertile more widely than we in the U.S. have, and we suggest it’s time to think more carefully about terminology. For us, it’s “subfertile ‘til proven otherwise!”


If you or someone you know is concerned about issues of fertility, we encourage you to call us at 919.230.2100 to learn more or click to schedule an appointment.

Dr. Kim Barrows Interviewed by ABC News in Grand Rapids, Michigan June 12, 2025
June 14, 2025
Dr. Kim Barrows Interviewed about Restorative Reproductive Medicine by ABC News in Grand Rapids, Michigan 
By Carolyn Plican May 30, 2025
In anticipation of an announcement from the Trump administration regarding solutions for infertility, and in preparation for World Infertility Awareness Month in June, the International Institute for Restorative Reproductive Medicine (IIRRM) has issued a statement about the growing promise and prominence of restorative reproductive medicine (RRM).
RRM parents,following years of unexplained infertility and no results working with other specialists
By Patient Testimonial May 24, 2025
Patients Erica and John found Reply following years of unexplained infertility and no results working with other specialists—“we just didn’t know there was anything else out there.” They followed the typical pattern of multiple underlying factors that could be identified and treated. With comprehensive RRM care they were able to conceive and gave birth to a healthy, beautiful baby girl. They emphasize that “if you can figure out ‘why,’ that’s half the battle.” Their testimonial below was recorded, transcribed, and edited for length.
Dr. Joseph Stanford, RRM Clinician, University of Utah
By Deborah Colloton May 24, 2025
In a first of its kind, a presidential chair in restorative reproductive medicine (RRM) has been established at the University of Utah Spencer Fox Eccles School of Medicine in Salt Lake City, Utah. This new academic chair, the “Joseph B. Stanford, M.D., and Kathleen B. Stanford Presidential Chair in Restorative Reproductive Medicine,” honors the pioneering work and commitment of Dr. and Mrs. Stanford to the RRM medical discipline.
Medical Text Books
By Deborah Colloton May 24, 2025
A major milestone for restorative reproductive medicine has been achieved with the launch of the new medical journal, Journal of Restorative Reproductive Medicine (JRRM). “Our vision is that JRRM will disseminate and promote evidence-based information to support and restore human fertility and reproductive health,” wrote editor-in-chief Dr. Joseph B. Stanford in a welcome commentary. The peer-reviewed, open-access journal is published by the International Institute for Restorative Reproductive Medicine (IIRRM), and will provide the opportunity to expand and deepen the knowledge base for restorative reproductive medicine (RRM).
Reply Fertility
By Carolyn Plican February 21, 2025
Response to Trump Executive Order on IVF: Reply Fertility Urges Restorative Reproductive Medicine for Patients Facing Infertility
A person is holding a newborn baby wearing a white hat
July 3, 2024
“After over a year of trying and a miscarriage, it just felt like there was no hope and no way out of this situation. It seemed like there was no solution, that I would always be sick, and that we would never get to hold any of our children in this life.”
By Deborah Colloton April 30, 2024
Two things struck me during reflections surrounding 2024 “National Infertility Awareness Week”:
A man and a woman are sitting on a couch talking to a woman.
August 24, 2023
Discover how restorative reproductive medicine helps couples restore natural fertility. Learn why RRM could be your answer—explore now!
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