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RRM Research

RRM Research

Restorative reproductive medicine (RRM) research

International single & multi-center clinical studies support Reply's results, showing restorative reproductive medicine's cooperative approach to treating infertility has similar efficacy to IVF, at a fraction of the cost and with better health outcomes for families. There is an alternative to IVF. 

RRM Published Research

Several restorative reproductive medicine studies have now been published showing the efficacy of RRM treatment for infertility. RRM is an international movement to improve reproductive healthcare with a different approach; finding the root causes of infertility, then treating them in a cooperative manner.

Reply Fertility Clinic Statistics - 2 Year Analysis

  • infertility was multifactorial with an average 4 contributing underlying factors per couple
  • 50% of Reply couples achieve pregnancy within the first 12 months of treatment.
  • 69% of couples successfully conceive within 18 months after completing the full course of treatment at Reply.
  • Average time to pregnancy at Reply is 8 months.

STORRM

Reply Fertility is a participant in the global research registry, Surveillance of Treatment Outcomes for Restorative Reproductive Medicine (STORRM), led by the International Institute for Restorative Reproductive Medicine (IIRRM). When you join Reply Fertility, you are joining a global leader pioneering fertility care.

Download STORRM Study Summary

Read the Published RRM Research

International Natural Procreative Technology Evaluation and Surveillance of Treatment for Subfertility (iNEST)

August 2022 


Published: Human Reproduction Open

  • 834 women; 10 RRM clinics (Canada, Poland, UK and USA)
  • 57% pregnancy rate
  • 44% live birth rate
  • The mean number of diagnoses per couple was 4.7
  • An ovulation-related disorder diagnosed in 87%
  • Endometriosis in 31%
  • Nutritional disorders in 47%
  • Abnormalities of semen analysis in 24%. 

Pregnancy outcomes from a restorative infertility treatment model.

April 2021 (Australia)


Published: medRxIV

  • 162 couples; average female age 33.7
  • 2.8 years prior mean time trying
  • adj. cum. live birth 57.4% @ 24 months

Stratification of fertility potential according to cervical mucus symptoms: achieving pregnancy in fertile and infertile couples

October 2019 (Australia)


Published: Human Fertility

  • 384 women; consecutive clinical cohort
  • 28% women aged >35 years
  • 51% of cohort with infertility ≥12 months
  • adj. cum. conception 62.5% @ 24 months

Healthy singleton pregnancies from restorative reproductive medicine (RRM) after failed IVF

July 2018 (Ireland)


Published: Frontiers of Medicine

  • 403 couples; average female age 37.2
  • 100% had prior IVF (avg 2.1 attempts) w/ 5% live birth rate
  • 5.8 years prior mean time trying
  • adj. cum. live birth 32.1% w/ 92% birth at 37+ weeks

Natural conception rates in subfertile couples following fertility awareness training

February 2017 (Germany)


Published: Archives of Gynecology & Obstetrics

  • 187 subfertile women; aged 21-47
  • 3.5 years prior mean time trying AFTER Fertility Awareness Training conception rate 38% @ 8 months (for all couples)
  • conception rate 56% @ 8 months (for couples trying 1-2 yrs)

Natural procreative technology for infertility and recurrent miscarriage - Outcomes in a Canadian family practice

May 2012 (Canada)


Published: Canadian Family Physician

  • 108 couples; average female age 35.4
  • 30% prior ART; 3.2 years prior mean time trying
  • adj. cum. conception 73% @ 24 months
  • adj. cum. live birth 66% @ 24 months

Outcomes from treatment of infertility with natural procreative technology in an Irish general practice

Sept-Oct 2008 (Ireland)


Published: Journal of the American Board of Family Medicine

  • 1072 couples; average female age 35.8
  • 33% prior ART; 5.6 years prior mean timetrying
  • adj. cum. conception 64.8% @ 24 months
  • adj. cum. live birth 52.8% @ 24 months

Take the first step

Find & treat the underlying causes.

“ART [assisted reproductive technology such as IVF] increases the risk of preterm birth, low birth weight, and birth defects. These risks are particularly observed in multiple births; however, a certain risk increase remains also in singletons born after ART….In light of the safety of future ART generations, one rule should apply to all ART: if a method is clinically unnecessary, then avoid it.”

-- Pinborg A., Wennerholm U-B., Bergh C. Long-term outcomes for children conceived by assisted reproductive technology. Fertility and Sterility; September 2023; Vol 120, No. 3, Pt.1, p 453-454.

“ART offspring have an increased risk of NCD (noncommunicable diseases), such as malignancies, asthma, obesity, metabolic syndrome, diabetes, cardiovascular diseases, and neurodevelopmental and psychiatric disorders. There are still many controversies in this field and much remains unknown.”

-- Zhang S., Luo Q., Meng R., Yan J., Wu Y., Huang H.; Long-term health risk of offspring born from assisted reproductive technologies; Journal of Assisted Reproduction and Genetics; November 2023.

“There are substantial concerns about expanding use of IVF, including high cost and impact on neonatal outcomes. Epidemiologic studies have demonstrated higher incidence of preterm birth (PTB), low birthweight (LBW), and birth defects among children conceived through IVF….Our findings support efforts to encourage women to give an adequate trial of the least invasive fertility treatment that may work for them.”

-- Sanders, Jessia N, Simonsen Sara E., Porucznik Christina A., Hammoud Ahmad O., Smith Ken R., Stanford, Joseph B; Fertility treatments and the risk of preterm birth among women with subfertility: a linked-data retrospective cohort study; BMC Reproductive Health; March 2022

Expert findings about IVF concerns and risks

Our patient reviews

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